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Hey buddy nurse here, indeed smoking can alter the effects of this drugs to your wife, most drugs you told me are acting in the brain or central nervous system this is also where smoking acts and competes with medication either by antagonizing the effect or supporting the effect of the other, morphine for example is an opioid analgesic which can cause sedation and central nervous syatem depression and gabapentin is an anticonvulsant can have depressing effect to the brain but smoking can cause SNS stimulation which is the opposite, i suggest that you tell your wife to stop from smoking and see your doctor if more untoward reaction occur, take care. Watch also And flomax cialis!.

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