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Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisone to Prednisolone is impaired. Corticosteroids, including prednisone, are commonly used to suppress the immune system plays an important role. Prednisone typically does not produce immediate effects and must be used for several days before the needed effect is achieved. Prednisolone is used for treating allergies, arthritis, breathing problems, certain blood disorders, certain eye diseases, cancer or psoriasis. Prednisolone is used for treating leukemia, lymphomas and autoimmune hemolytic anemia. Deltasone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly.